Journal of Synchrotron Radiation 2013-03-01

Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells.

Erin J Sheridan, Christopher J D Austin, Jade B Aitken, Stefan Vogt, Katrina A Jolliffe, Hugh H Harris, Louis M Rendina

Index: J. Synchrotron Radiat. 20(Pt 2) , 226-33, (2013)

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Abstract

The first example of synchrotron X-ray fluorescence imaging of cultured mammalian cells in cyclic peptide research is reported. The study reports the first quantitative analysis of the incorporation of a bromine-labelled cyclic RGD peptide and its effects on the biodistribution of endogenous elements (for example, K and Cl) within individual tumor cells.