Il Farmaco 1993-10-01

Fungicidal and genotoxic activity of new substituted pyridazinones.

M L Carmellino, G Massolini, G Pagani, F Zani, G Leri

Index: Il Farmaco 48(10) , 1427-38, (1993)

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Abstract

Some 2-sulfonyl- and 2-acylderivatives of the 4,5-dichloro-3(2H)-pyridazinone were prepared in order to test their fungicidal activity. Interesting results, both in vitro and in vivo, were obtained in particular from the alkylsulfonyl-derivatives. Genotoxic activity of 3(2H)-pyridazinones was evaluated in vitro by the Bacillus subtilis rec-assay and the Salmonella-microsome reversion assay.