Journal of Dermatological Treatment 2008-01-01

Topical preparations for the treatment of psoriasis: results of a retrospective study over 15 years.

Anna Zampetti, Alessia Barone, Daniela Antuzzi, Paolo Amerio, Antonello Tulli, Claudio Feliciani, Pierluigi Amerio

Index: J. Dermatolog. Treat. 19(3) , 134-40, (2008)

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Abstract

Psoriasis requires lifelong treatments that depend on the extent, clinical forms and associated conditions.To retrospectively analyze which topical treatments were used, their efficacy, and potential advantages and disadvantages.A total of 666 patients admitted for the first time over 15 years who were topically treated were retrospectively reviewed and subdivided using clinical forms and PASI into four groups and four subgroups for the applied treatments. For each treatment the mean PASI was calculated daily: on the first, third and sixth day. An X sample statistical analysis and Mann--Whitney U-test were performed. The hospitalization time and correlation with the response to treatment were analyzed.A statistically significant response was recorded for every regimen. The best combination was clobetasol propionate plus eosin on alternate days with eosin plus cade oil. The highest score was recorded for the 'en plaques' psoriasis. The average length of treatment was of 7.5 days in the best combination. No statistically significant difference among the groups was recorded with respect to the length of hospitalization and PASI.The statistically significant response for all the topical treatments analyzed and recorded in this study does not exclude a potential benefit due to hospitalization per se.