Bioorganic & Medicinal Chemistry Letters 2014-05-01

Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidity.

Kouki Matsuda, Shinichiro Hattori, Yuji Komizu, Ryusho Kariya, Ryuichi Ueoka, Seiji Okada

Index: Bioorg. Med. Chem. Lett. 24(9) , 2115-7, (2014)

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Abstract

The anti-HIV-1 activity of cepharanthine (CEP), a natural product derived from Stephania cepharantha Hayata, was evaluated. CEP stabilized plasma membrane fluidity and inhibited HIV-1 envelope-dependent cell-to-cell fusion of HIV-1-infected cells as well as cell-free infection. It is suggested that CEP inhibited the HIV-1 entry process by reducing plasma membrane fluidity, and the plasma membrane is therefore an identical target to prevent viral infection.Copyright © 2014 Elsevier Ltd. All rights reserved.