Effect of 3, 4-ethylenedioxy-extension of thiophene core on the DNA/RNA binding properties and biological activity of bisbenzimidazole amidines

…, I Piantanida, M Bajić, L Glavaš-Obrovac

Index: Stolic, Ivana; Miskovic, Katarina; Magdaleno, Anahi; Silber, Ariel Mariano; Piantanida, Ivo; Bajic, Miroslav; Glavas-Obrovac, Ljubica Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2544 - 2554

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Citation Number: 27

Abstract

Novel bisbenzimidazoles (4–6), characterized by 3, 4-ethylenedioxy-extension of thiophene core, revealed pronounced affinity and strong thermal stabilization effect toward ds-DNA. They interact within ds-DNA grooves as dimmers or even oligomers and agglomerate along ds-RNA. Compounds 4–6 have shown moderate to strong antiproliferative effect toward panel of eight carcinoma cell lines. Compound 5 displayed the best inhibitory potential ...