Chemical Communications 2006-06-14

Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues.

Steven J Moss, Isabelle Carletti, Carlos Olano, Rose M Sheridan, Michael Ward, Vidya Math, Mohammad Nur-E-Alam, Alfredo F Braña, Ming Qiang Zhang, Peter F Leadlay, Carmen Méndez, José A Salas, Barrie Wilkinson

Index: Chem. Commun. (Camb.) (22) , 2341-3, (2006)

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Abstract

We report the directed biosynthesis of borrelidin analogues and their selective anti-proliferative activity against human cancer cell lines.