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e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases

P Wipf, DC Aslan, EC Southwick, JS Lazo

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 3 p. 313 - 317

Full Text: HTML

Citation Number: 23

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... 1 As part of a program to develop phosphatase inhibitors as mechanistic probes in cell biology and as potential antiproliferative agents, 2, 3 and 4 we have used combinatorial chemistry strategies to develop pharmacophores 1 and 2 ...

 Related Synthetic Route
1-(4-chlorophenyl)propan-1-ol Structure

13856-85-4

1-(4-chlorophen...

~%

2-amino-4-(4-chlorophenyl)-5-methylthiazole Structure

82632-77-7

2-amino-4-(4-ch...

4-Chlorobenzaldehyde Structure

104-88-1

4-Chlorobenzaldehyde

~%

2-amino-4-(4-chlorophenyl)-5-methylthiazole Structure

82632-77-7

2-amino-4-(4-ch...

Benzenemethanol, a-propyl- Structure

614-14-2

Benzenemethanol...

~%

5-Ethyl-4-phenyl-1,3-thiazol-2-amine Structure

34176-47-1

5-Ethyl-4-pheny...

Benzaldehyde Structure

100-52-7

Benzaldehyde

~%

5-Ethyl-4-phenyl-1,3-thiazol-2-amine Structure

34176-47-1

5-Ethyl-4-pheny...

1-(4-Chlorophenyl)ethanol Structure

3391-10-4

1-(4-Chlorophen...

~%

2-amino-4-(4-chlorophenyl)thiazole Structure

2103-99-3

2-amino-4-(4-ch...

4-Chlorobenzaldehyde Structure

104-88-1

4-Chlorobenzaldehyde

~%

2-amino-4-(4-chlorophenyl)thiazole Structure

2103-99-3

2-amino-4-(4-ch...

4-Chlorobenzaldehyde Structure

104-88-1

4-Chlorobenzaldehyde

~%

4'-Chloropropiophenone Structure

6285-05-8

4'-Chloropropio...

4-Chlorobenzaldehyde Structure

104-88-1

4-Chlorobenzaldehyde

~%

1-(4-Chlorophenyl)ethanone Structure

99-91-2

1-(4-Chlorophen...

4-Chlorobenzaldehyde Structure

104-88-1

4-Chlorobenzaldehyde

~%

1-(4-Chlorophenyl)ethanol Structure

3391-10-4

1-(4-Chlorophen...

(S)-(+)-1,2-DIPHENYLETHANOL Structure

5773-56-8

(S)-(+)-1,2-DIP...

~%

2-Thiazolamine,4,5-diphenyl- Structure

6318-74-7

2-Thiazolamine,...

Benzaldehyde Structure

100-52-7

Benzaldehyde

~%

2-Thiazolamine,4,5-diphenyl- Structure

6318-74-7

2-Thiazolamine,...

1-phenyl-1-dodecanol Structure

1851-93-0

1-phenyl-1-dodecanol

~%

laurophenone Structure

1674-38-0

laurophenone

Benzaldehyde Structure

100-52-7

Benzaldehyde

~%

laurophenone Structure

1674-38-0

laurophenone

4-Chlorobenzaldehyde Structure

104-88-1

4-Chlorobenzaldehyde

~%

1-(4-Chlorophenyl)-1-pentanone Structure

25017-08-7

1-(4-Chlorophen...

Benzaldehyde Structure

100-52-7

Benzaldehyde

~%

Benzenemethanol, a-propyl- Structure

614-14-2

Benzenemethanol...

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One pot synthesis using supported reagents system KSCN/SiO 2...

[Tetrahedron, , vol. 62, # 14 p. 3201 - 3213]

Detail Synthetic Route


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