Tetrahedron Letters

A base-promoted deprotection of 1, 3-dioxolanes to ketones

C Yuan, L Yang, G Yue, T Yu, W Zhong, B Liu

Index: Yuan, Changchun; Yang, Li; Yue, Guizhou; Yu, Tianzi; Zhong, Weiming; Liu, Bo Tetrahedron Letters, 2012 , vol. 53, # 51 p. 6972 - 6976

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Citation Number: 2

Abstract

An effective deprotection methodology of dioxolanes was developed, affording moderate to excellent yield via a LTMP-promoted reaction in THF, which displays admirable chemoselectivity in the presence of dimethylketal, 1, 3-dioxane, 1, 3-dithiane, or other acid- sensitive protective groups.