New England Journal of Medicine 2014-05-15

Oxantel pamoate-albendazole for Trichuris trichiura infection.

Jennifer Keiser, Benjamin Speich, Jürg Utzinger

Index: N. Engl. J. Med. 370(20) , 1953-4, (2014)

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Abstract

TO THE EDITOR: Speich et al. (Feb. 13 issue)1 report that treatment with oxantel pamoate–albendazole was significantly more efficacious against Trichuris trichiura than a single dose of albendazole or mebendazole. The 2-day regimen used in the study has considerable logistical implications in large-scale chemotherapy programs, and it remains unclear whether oxantel pamoate–albendazole administered as a single dose can achieve similar efficacy. In a study of the activity of oxantel pamoate against T. muris in mice, Keiser and colleagues found that oxantel pamoate–albendazole administered in a single-dose regimen had an antagonistic effect.2 Although a single dose of albendazole and mebendazole, as . . .