Cell Cycle 2009-06-15

A novel mode of FoxM1 regulation: positive auto-regulatory loop.

Marianna Halasi, Andrei L Gartel

Index: Cell Cycle 8(12) , 1966-7, (2009)

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Abstract

Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisingly, investigation of the mechanism of action of FoxM1 inhibitors revealed a novel mode of positive auto-regulation of FoxM1.