A series of N44-[[4-alkoxy-3-[(dialkylamino) methyl] phenyl] amino]-2-pyrimidinyl]-N'- phenylguanidines have been synthesized for antifilarial evaluation. Reaction of the appropriate benzenamines with N-cyanoguanidine, followed by condensation of the resultant N-phenylimidodicarbonimidic diamides (V) with ethyl 4, 4, 4-trifluoro-3- oxobutanoate provided the intermediate N-(4-hydroxy-2-pyrimidinyl)-N'-phenylguanidines ...
