Biulleten' eksperimental'noi biologii i meditsiny 1992-11-01

[The effect of cyclosporin A on the islet cells of mice].

E D Gol'dberg, V A Eshchenko, V D Bovt, A Ia Tolok

Index: Biull. Eksp. Biol. Med. 114(11) , 491-2, (1992)

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Abstract

The action of immunosuppressive agent ciclosporin A on the insular apparatus was studied with an original method of cytochemical zinc detection in experiments on mice. The drug was found to lower zinc levels in pancreatic beta-cells. In ciclosporin A pretreatment the sensitivity of mice to zinc-binding diabetogenic agent enhanced.