Ophthalmologica 1990-01-01

Intraocular tolerance to silicone oils of different specific gravities. An experimental study.

C Eckardt, D Schmidt, M Czank

Index: Ophthalmologica 201(3) , 133-9, (1990)

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Abstract

Different methylphenylsilicone (MPS) and fluorosilicone (FS) oils having a higher specific gravity than water were investigated as vitreous replacements. Their intraocular tolerance in vitrectomized aphakic rabbit eyes was evaluated for periods of up to 4 months and compared to that of regular polydimethylsilicone oil (PDMS). Weakly fluorinated FS and weakly phenylated MPS showed a presumably toxic effect on the retina. As compared to highly fluorinated FS, highly phenylated MPS showed better intraocular tolerance; however, inflammatory reaction was slightly more extensive than in eyes filled with PDMS.