Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogs

A Thurkauf, B De Costa, S Yamaguchi…

Index: Thurkauf, Andrew; Costa, Brian de; Yamaguchi, Shun-ichi; Mattson, Mariena V.; Jacobson, Arthur E.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1452 - 1458

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Citation Number: 32

Abstract

Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay. In addition, we determined the binding affinities of the compounds for PCP acceptor sites in rat brain membranes labeled with [3H]-1-[1-(2-thienyl) cyclohexyl] piperidine. Many of the analogues were protective against MES seizures (EDms of 5-41 ...