Annals of the Lyceum of Natural History of New York 2009-08-01

Differentiation and apoptosis in UVA-irradiated cells treated with furocoumarin derivatives.

Giampietro Viola, Alessia Salvador, Daniela Vedaldi, Francesco Dall'Acqua, Nicoletta Bianchi, Cristina Zuccato, Monica Borgatti, Ilaria Lampronti, Roberto Gambari

Index: Ann. N. Y. Acad. Sci. 1171 , 334-44, (2009)

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Abstract

In this review we summarize the structure and biological effects of linear and angular psoralens. These compounds exhibit interesting biological effects on the cell cycle, apoptosis and differentiation. These molecules should be considered promising drugs in the therapy of several diseases, including psoriasis, mycosis fungoides and cancer. Also, preclinical data demonstrate a possible use of these molecules for the treatment of beta-thalassemia and other hematological disorders.