Nucleosides, Nucleotides & Nucleic Acids 2005-01-01

Rapid access to 2'-branched-carbocyclic nucleosides and their 4'-epimers from 2-alkyl-cyclopentene-1-ones.

J C Meillon, L Griffe, R Storer, G Gosselin

Index: Nucleosides Nucleotides Nucleic Acids 24(5-7) , 695-9, (2005)

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Abstract

2-Methyl-2-cyclopentene-1-one was used as starting material in a novel route toward 2'-branchedcarbocyclic nucleosides. This methodology was efficiently adapted to the preparation of 4'-epicarbocycles. A series of this new class of molecules was synthesized as potential antiviral compounds.