Synthesis and antitumor activity of phagocytic conjugates of 5-fluorouracil with albumin

…, AI Chertkova, MN Preobrazhenskaya

Index: Bukhman, V. M.; Brusentsov, N. A.; Kikot', B. S.; Volodin, Yu. Yu.; Chertkova, A. I.; Preobrazhenskaya, M. N. Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 8 p. 575 - 580 Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 8 p. 58 - 65

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Abstract

The creation of phagocytic forms of cytostatics is a promising method for increasing the effectiveness of antitumor chemotherapy [1-4]. These forms accumulate in the organs of the mononuclear phagocyte system (MPS)--liver, spleen, bone marrow, and lymph nodes. By varying the method and frequency of administration, and also the dosage, it is possible to produce a selective accumulation of a drug in one or more of these organs, so that the ...