General approach to 2, 4-dialkyl-3-carboxybuty-rolactones: An efficient synthesis of (±)-striatisporolide A and (±)-lichesterinic acid

RM Patel, NP Argade

Index: Patel, Ramesh M.; Argade, Narshinha P. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 8 p. 1071 - 1075

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Citation Number: 6

Abstract

Abstract: Starting from 2-alkylidene-3-methylsuccinimides, simple and efficient synthesis of the natural products striatisporolide A, lichesterinic acid and lichesterylic acid have been demonstrated via an acid catalyzed hydrolysis, esterification, OsO 4-dihydroxylation and dehydrative cyclization pathway.