Bioorganic & Medicinal Chemistry Letters 2007-06-15

Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging.

Bao Teng, Yunpeng Bai, Yu Chang, Shizhen Chen, Zhaolong Li

Index: Bioorg. Med. Chem. Lett. 17 , 3440, (2007)

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Abstract

The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine-N,N'-diacetic acid (EDDA) as coligands. The effects of different spacers between thymidine analog with HYNIC on radiochemical yield were also studied.