Molecules 2008-01-01

A convenient synthesis of amino acid methyl esters.

Jiabo Li, Yaowu Sha

Index: Molecules 13(5) , 1111-9, (2008)

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Abstract

A series of amino acid methyl ester hydrochlorides were prepared in good to excellent yields by the room temperature reaction of amino acids with methanol in the presence of trimethylchlorosilane. This method is not only compatible with natural amino acids, but also with other aromatic and aliphatic amino acids.