Farmakologiia i toksikologiia 1982-01-01

[Acetylation of sulfadimezine and ethazole in rats].

Iu F Krylov, E T Lil'in, M M Vaniukov, A R Monastyrskaia, I V Isaeva

Index: Farmakol. Toksikol. 45(4) , 85-8, (1982)

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Abstract

The paper is concerned with studies into acetylation of sulfadimezine (S) in Wistar, August and random-bred rats and into that of ethazole in Wistar rats. Age-associated differences in S acetylation were examined in random-bred animals and the effect of phenobarbital on S acetylation was investigated in Wistar and August rats. Interlinear differences as regards S acetylation were found to be absent in the presence of sexual dimorphism as to the sign under study: the females were disclosed to be rapid while males to be slow S acetylators. Administration of phenobarbital did not lead to appreciable changes in the rat acetylator phenotypes. However there was tendency towards retardation of S acetylation in both the strains and both sexes. No sexual dimorphism as regards S acetylation was found in sexually immature random-bred rats whose acetylator phenotypes do not differ from those of adult females, or the development of sexual dimorphism in sexually mature animals. No sexual dimorphism as regards ethazole acetylation was shown in Wistar rats.