BMC Structural Biology 2007-11-01

The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.

Marcel Winnig, Bernd Bufe, NicoleA Kratochwil, JayP Slack, Wolfgang Meyerhof

Index: BMC Struct. Biol. 7 , 66, (2007)

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Abstract

Differences in sweet taste perception among species depend on structural variations of the sweet taste receptor. The commercially used isovanillyl sweetener neohesperidin dihydrochalcone activates the human but not the rat sweet receptor TAS1R2+TAS1R3. Analysis of interspecies combinations and chimeras of rat and human TAS1R2+TAS1R3 suggested that the heptahelical domain of human TAS1R3 is crucial for the activation of the sweet receptor by neohesperidin dihydrochalcone.