Total synthesis of neooxazolomycin

…, K Takahashi, J Ishihara, S Hatakeyama

Index: Onyango, Evans Otieno; Tsurumoto, Joji; Imai, Naoko; Takahashi, Keisuke; Ishihara, Jun; Hatakeyama, Susumi Angewandte Chemie - International Edition, 2007 , vol. 46, # 35 p. 6703 - 6705

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Citation Number: 59

Abstract

Neooxazolomycin and oxazolomycin A, originally isolated from a strain of Streptomyces by Uemura and co-workers in 1985,[1] together with the seven other congeners identified to date constitute a family of structurally unique oxazole polyene lactam-lactone antibiotics. These oxazolomycins were found to exhibit wide-ranging and potent antibacterial and antiviral activities as well as in vivo antitumor activity. Their intriguing molecular ...