Biotechnology Letters 2005-01-01

High-yield conversion of (R)-2-octanol from the corresponding racemate by stereoinversion using Candida rugosa.

Yao Nie, Yan Xu, Xiao Qing Mu, Yan Tang, Juan Jiang, Zhi Hao Sun

Index: Biotechnol. Lett. 27(1) , 23-6, (2005)

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Abstract

Whole cells of Candida rugosa catalyzed the conversion of (R)-2-octanol from the corresponding racemate with the optical purity of 97% e.e. and yield of 92% in 10 h. The product was formed through a stereoinversion involving enantioselective oxidation and asymmetric reduction with 2-octanone as the intermediate.