Aryl coupling reactions of pyrazolo [3, 4-d] pyrimidin-4-yl radicals

JB Press, NH Eudy, GO Morton

Index: Press, Jeffery B.; Eudy, Nancy H.; Morton, George O. Journal of Organic Chemistry, 1983 , vol. 48, # 24 p. 4605 - 4611

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Citation Number: 8

Abstract

3 forward synthesis of 4 could be envisioned as a one-step Gomberg-Bachmann-Hey aryl coupling reaction3 between readily available 4-aminopyrazolo [3, 4-d] pyrimidines (5) 4 and a variety of aromatic solvents. This method would allow for specific control of the site for arylation as well as for the preparation of numerous analogues from only a few common radical intermediates. A similar approach to the preparation of 6, the purine analogue of 4, ...