Organic & Biomolecular Chemistry 2009-04-07

Synthesis of azepino[4,5-b]indolones via an intermolecular radical oxidative substitution of N-Boc tryptamine.

Paul E Reyes-Gutiérrez, Rubén O Torres-Ochoa, Roberto Martínez, Luis D Miranda

Index: Org. Biomol. Chem. 7(7) , 1388-1396, (2009)

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Abstract

A two-step protocol for the synthesis of azepino[4,5-b]indolone derivatives featuring a xanthate radical oxidative aromatic substitution on the N-Boc protected tryptamine, using dilauroyl peroxide (DLP) as initiator and oxidant, is described.