Hepato-gastroenterology 2011-01-01

Early effects of oral administration of lafutidine with peppermint oil, compared with lafutidine alone, on intragastric pH values.

Hiroshi Iida, Masahiko Inamori, Tahashi Uchiyama, Hiroki Endo, Kunihiro Hosono, Tomoyuki Akiyama, Yasunari Sakamoto, Koji Fujita, Hirokazu Takahashi, Masato Yoneda, Tomoko Koide, Chikako Tokoro, Ayumu Goto, Yasunobu Abe, Noritoshi Kobayashi, Hiroyuki Kirikoshi, Kensuke Kubota, Satoru Saito, Atsushi Nakajima

Index: Hepatogastroenterology. 58(105) , 235-8, (2011)

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Abstract

Ideally, medications for the treatment of acid-related diseases should have a rapid onset of action to promote hemostasis and the resolution of symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of lafutidine alone or combined with peppermint oil.Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 4 hours after a single oral administration of lafutidine (10 mg) or the administration of lafutidine (10 mg) with peppermint oil (0.64 mL). Each administration was separated by a 7-day washout period.No significant difference in the average pH was observed during the 4-hour period after the combined administration of lafutidine and peppermint oil and after the administration of lafutidine alone (median gastric pH: 5.09 versus 5.29; p = 0.3122).In H. pylori-negative healthy male subjects, an oral dose of lafutidine combined with peppermint oil did not increase the intragastric pH faster than lafutidine alone.