Journal of Asian Natural Products Research 2007-01-01

Microbial transformation of neoandrographolide by Aspergillus niger (AS 3.739).

Li-Xia Chen, Feng Qiu, Ge-Xia Qu, Xin-Sheng Yao

Index: J. Asian Nat. Prod. Res. 9(3-5) , 463-9, (2007)

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Abstract

The biotransformation of neoandrographolide (1) was investigated by using Aspergillus niger (AS 3.739). Five products were obtained and identified as 8(17),13-ent-labdadien-16,15-olid-19-oic acid (2), 19-hydroxy-8(17),13-ent-labdadien-16,15-olide (3), 18-hydroxy-8(17),13-ent-labdadien-16,15-olid-19-oic acid (4), 3alpha-hydroxy-8(17),13-ent-labdadien-16,15-olid-19-oic acid (5) and 8beta,19-dihydroxy-ent-labd-13-en-16,15-olide (6) by spectroscopic and chemical means. Products 4, 5 and 6 are new compounds.