Heterocycles 32. Efficient kinetic resolution of 1-(2-arylthiazol-4-yl) ethanols and their acetates using lipase B from Candida antarctica

…, J Brem, M Moisă, MI Toşa, FD Irimie, V Zaharia

Index: Hapau, Denisa; Brem, Juergen; Moisa, Madalina; Tosa, Monica-Ioana; Irimie, Florin Dan; Zaharia, Valentin Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 94, p. 88 - 94

Full Text: HTML

Citation Number: 4

Abstract

Abstract In this paper we describe the chemoenzymatic synthesis of new enantiomerically enriched (R)-and (S)-1-(2-arylthiazol-4-yl) ethanols and their acetates by enzymatic enantioselective acetylation of the racemic alcohols rac-2a–d and by methanolysis of the corresponding racemic esters rac-3a–d mediated by lipase B from Candida antarctica (CaL- B) in non-aqueous media. In terms of stereoselectivity and activity, both procedures, ...