Troger's bases 2'3 and 4 containing azole rings as substituents on the aromatic moiety have been synthesized for the first time. ... Troger's base 1 (2'8-dimethyl-5 ,Il-methano-5,6,11,12-tetra - hydrodibenzo[b,fl[ 1,5]diazocine), first synthesized by Troger in 1887,' is a concave chiral molecule. Prelog resolved it using chiral chromatography,* and more recently the resolution was carried out via diastereoisomeric salt formation .3 Troger's base analogues provide ...
