Orally Active Non-Peptide Fibrinogen Receptor (GpIIb/IIIa) Antagonists: Identification of 4-[4-[4-(Aminoimino methyl) phenyl]-1-piperazinyl]-1-piperidineacetic Acid as a …

…, B Evans, S Hindley, BD Judkins, HA Kelly…

Index: Eldred, Colin D.; Evans, Brian; Hindley, Sean; Judkins, Brian D.; Kelly, Henry A.; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3882 - 3885

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Citation Number: 50

Abstract

Inhibition of ADP (10 pM)-induced aggregation in human gelfiltered platelets (GFP) containing fibrinogen (500 pglmL) and aspirin (100 pM). IC50= compound concentration producing 50% inhibition of aggregation. 16 IC50 values are expressed as the mean of two determinations (maximum 3-fold variation in each experiment). Duration of action at 5 mgkg iv in the marmoset was 87 min. Inhibition of ADP (10 pM)-induced aggregation measured ...