Oxidation of 7, 8??diaminotheophylline with lead tetraacetate and reaction of the oxidation product, 6??cyanoimino??5??diazo??1, 3??dimethylpyrimidine??2, 4??dione with …

T Ueda, N Yatsuzuka, SI Nagai, K Okada…

Index: Ueda; Yatsuzuka; Nagai; Okada; Takeichi; Segi; Sakakibara Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 1 p. 141 - 145

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Citation Number: 2

Abstract

Abstract Oxidation of 7, 8-diaminotheophylline (1) with lead tetraacetate in refluxing toluene gave a mixture of 3-amino-5, 7-dimethylpyrimido [4, 5-e][1, 2, 4] triazine-6, 8-dione (2) and 6- cyanoimino-5-diazo-1, 3-dimethylpyrimidine-2, 4-dione (4). The latter was transformed to 2 by the reaction with 1-propanethiol in quantitative yield. The reaction of 4 with methanol, ethanol and 1-propanol in the presence of rhodium (II) acetate gave 5-alkoxy-6-(2-alkyl-3- ...