Bioscience, Biotechnology, and Biochemistry 1996-02-01

Inhibitory effects of caffeic acid ethyl ester on H2O2-induced cytotoxicity and DNA single-strand breaks in Chinese hamster V79 cells.

T Nakayama, M Yamada, T Osawa, S Kawakishi

Index: Biosci. Biotechnol. Biochem. 60(2) , 316-8, (1996)

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Abstract

Cytotoxicity and DNA single-strand breaks caused by H2O2 were assessed by a colony formation assay and a DNA precipitation assay, respectively, with Chinese hamster V79 cells. In both assays, caffeic acid ethyl ester showed protective effects. The structure-activity relationship showed that the o-dihydroxy structure of caffeic acid ethyl ester was essential for the protective effects.