Applied Physiology, Nutrition, and Metabolism 2012-10-01

Vaccenic acid in serum triglycerides is associated with markers of insulin resistance in men.

Michael A Zulyniak, Jessica C Ralston, Amy J Tucker, Kathy A MacKay, Lyn M Hillyer, Paul D McNicholas, Terry E Graham, Lindsay E Robinson, Alison M Duncan, David W L Ma, David M Mutch

Index: Appl. Physiol. Nutr. Metab. 37(5) , 1003-7, (2012)

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Abstract

Serum triglyceride levels are associated with metabolic disorders; however, it remains unclear whether the fatty acid (FA) composition of triglycerides is also changed. Although there were no differences in circulating triglyceride levels between normoglycaemic-normoinsulinaemic and hyperglycaemic-hyperinsulinaemic men, inspection of individual FA revealed that vaccenic acid was enriched with hyperglycaemia-hyperinsulinaemia. Moreover, vaccenic acid levels were positively correlated with insulin and HOMA-IR. This reinforces that examination of individual FA in the context of insulin resistance is warranted.