Synthesis

Chromium (II) Reagents; 1. Reduction of α-Acetylenic Ketones to trans-Enones

AB Smith III, PA Levenberg, JZ Suits

Index: Smith, Amos B.; Levenberg, Patricia A.; Suits, Joan Z. Synthesis, 1986 , # 3 p. 184 - 189

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Citation Number: 17

Abstract

Chromium (ll) Reductions With two minor exceptions (3d and 3e), treatment of the ocacetylenic ketones listed in Table 2 with chromium (ll) sulfate in aqueous dimethylformamide led to the respective transcnones (Scheme C and Table 3). Yields ranged from 40* 85%. If great care was taken to exclude oxygen from the reaction mixture, the reduction could be accomplished with as few as 2.5 equivalents of chromium (II); for ...