Chemical Communications 2010-05-21

Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation.

Li Cui, Longwu Ye, Liming Zhang

Index: Chem. Commun. (Camb.) 46 , 3351-3353, (2010)

Full Text: HTML

Abstract

A surprisingly efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation is developed. This reaction involves a key gold catalysis and shows generally high regioselectivities and good to excellent diastereoselectivities.