Rapid Enabling of Negishi Couplings for a Pair of mGluR5 Negative Allosteric Modulators

A Gontcharov, JR Dunetz

Index: Liu, Zhichang; Xiang, Jiannan Organic Process Research and Development, 2006 , vol. 10, # 2 p. 285 - 288

Full Text: HTML

Citation Number: 1

Abstract

... and at the iodide via transition-metal-catalyzed cross-coupling (Scheme 1). The initial procedure for chloride ... Figure 3. Revised semibatch process for Negishi coupling with slow addition of 7a ... 1) nonbasic impurities (eg, trace 5, PPh 3 ) would be retained in the organic layer, and ...