A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro

…, G Stewart, E Rideau, NJ Westwood…

Index: Zhou, Linna; Stewart, Gavin; Rideau, Emeline; Westwood, Nicholas J.; Smith, Terry K. Journal of Medicinal Chemistry, 2013 , vol. 56, # 3 p. 796 - 806

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Citation Number: 18

Abstract

Recently, the World Health Organization approved the nifurtimox–eflornithine combination therapy for the treatment of human African trypanosomiasis, renewing interest in nitroheterocycle therapies for this and associated diseases. In this study, we have synthesized a series of novel 5-nitro-2-furancarboxylamides that show potent trypanocidal activity,∼ 1000-fold more potent than nifurtimox against in vitro Trypanosoma brucei with ...