Twenty four novel 2-[3-(4-bromo-2-fluorobenzyl)-4-oxo-3, 4-dihydro-1-phthalazinyl] acetic acid amides were synthesized from phthalic anhydride and were subjected to in vitro and in vivo evaluation against log-and starved phase of mycobacterial species and Mycobacterium tuberculosis isocitrate lyase enzyme inhibition studies. Among the compounds screened, 2- (2-(4-bromo-2-fluorobenzyl)-1, 2-dihydro-1-oxophthalazin-4-yl)-N-(2, 6-dimethylphenyl) ...
