Organic Letters 2004-08-05

BINAP/1,4-diamine-ruthenium(II) complexes for efficient asymmetric hydrogenation of 1-tetralones and analogues.

Takeshi Ohkuma, Tomonori Hattori, Hirohito Ooka, Tsutomu Inoue, Ryoji Noyori

Index: Org. Lett. 6(16) , 2681-3, (2004)

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Abstract

A combined system of a RuCl(2)(binap)(1,4-diamine) complex and t-C(4)H(9)OK in i-C(3)H(7)OH catalyzes enantioselective hydrogenation of various 1-tetralone derivatives and some methylated 2-cyclohexenones. Hydrogenation of 2-methyl-1-tetralone under dynamic kinetic resolution gives the cis alcohol with high ee. [reaction: see text]