Synthesis and antiviral activity of 1-[2-(allyloxy) ethoxymethyl]-and 1-[1, 3-di-(allyloxy)-2-propoxymethyl] pyrimidines

MS Novikov, AA Ozerov, AK Brel', EI Boreko…

Index: Novikov, M. S.; Ozerov, A. A.; Brel', A. K.; Boreko, E. I.; Korobchenko, L. V.; Vladyko, G. V. Pharmaceutical Chemistry Journal, 1994 , vol. 28, # 2 p. 110 - 113 Khimiko-Farmatsevticheskii Zhurnal, 1994 , vol. 28, # 2 p. 26 - 28

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Citation Number: 2

Abstract

Acyclovir [1, 2] and ganciclovir [3-5] are the most well-known representatives of the acyclic analogs of nucleosides and exhibit a powerful virus-inhibiting effect with respect to a broad spectrum of herpes viruses. The pyrimidine analogs of acyclovir [6-11] and ganciclovir [12- 14] do not display appreciable antiviral activity, since they do, not play a role in the substrates of virus-specific enzymes [15]. An exception is the 1-(1, 3-dihydroxy-2- ...