Synthesis and histamine H 3 receptor activity of 4-(n-alkyl)-1H-imidazoles and 4-(ω-phenylalkyl)-1H-imidazoles

…, A Gaffar, WMPB Menge, H Timmerman

Index: De Esch; Gaffar; Menge; Timmerman Bioorganic and medicinal chemistry, 1999 , vol. 7, # 12 p. 3003 - 3009

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Citation Number: 22

Abstract

The influence of lipophilic moieties attached to a 4-1H-imidazole ring on the histamine H3 receptor activity was systematically investigated. Series of 4-(n-alkyl)-1H-imidazoles and 4- (ω-phenylalkyl)-1H-imidazoles were prepared, with an alkyl chain varying from 2–9 methylene groups and from 1–9 methylene groups, respectively. The compounds were tested for their activity on the H3 receptor under in vitro conditions. For the 4-(n-alkyl)-1H- ...