Archiv der Pharmazie (Weinheim) 2006-09-01

Chromium(III) complexes of D-glucosaminic acid and their effect on decreasing blood sugar in vivo.

Sheng-Ju Ou, Guang Chen, Zhi-Hua Lin, Zhi-Ping Bai, Chun-Ying Duan, Cai-Ping Mao

Index: Arch. Pharm. (Weinheim) 339(9) , 527-30, (2006)

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Abstract

Two chromium(III) complexes of glucosaminic acid were synthesized by neutralization and exchange reaction. The formation of 1 : 1 and 2 : 3 (Cr : glucosaminate) complexes was confirmed by elemental analyses and spectroscopic studies. The effect of the complexes on decreasing blood sugar was investigated on type-2 diabetes model rats induced by tetraoxypyrimidine. The results indicated that the effect on decreasing blood sugar was comparable to that of picolinate chromium complex (Cr(pic)(3)) currently used world wide.