Evidence for SN 2 (P) mechanism in the phosphorylation of alkaline phosphatase by substrates

A Williams, RA Naylor

Index: Williams,A.; Naylor,R.A. Journal of the Chemical Society [Section] B: Physical Organic, 1971 , p. 1973 - 1979

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Citation Number: 27

Abstract

Michaelis–Menten parameters have been measured for a series of alkyl-, aryl-, and arylamido-phosphates as substrates of alkaline phosphatase. Kinetic parameters for p- bromophenylamido-phosphate were measured over a pH-range and the results, including inhibition by inorganic phosphate indicated the amides to be normal substrates of the enzyme. Little variation in the parameter k0 was observed for all substrates; the parameter ...

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