Design and synthesis of substituted compounds containing the 1, 4-benzodioxin subunit. New potential calcium antagonists

…, G Guillaumet, R Massingham, A Monteil…

Index: Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676

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Citation Number: 5

Abstract

New compounds possessing 1, 4-benzodioxin or its saturated analogous heterocyclic system were synthesized and tested for calcium antagonist activity. Biological differences were seen between the different modifications applied. These compounds have been shown to be representative of a novel series of calcium channel antagonists.