Organic Letters 2012-09-07

Potassium Boc-protected secondary aminomethyltrifluoroborates: synthesis and Suzuki-Miyaura cross-coupling reactions.

Gary A Molander, Inji Shin

Index: Org. Lett. 14(17) , 4458-61, (2012)

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Abstract

Seven potassium Boc-protected secondary aminomethyltrifluoroborates were prepared in a standardized two-step process. The Suzuki-Miyaura cross-coupling reaction was studied with this new class of nucleophiles, and a large variety of aryl and hetaryl chlorides provided the desired products in good to excellent yields, thereby allowing easy access to secondary aminomethyl substructures.

Structure	Name/CAS No.	Molecular Formula	Articles
	chloro(2-dicyclohexylphosphino-2',4',6'-triisoporpyl-1,1'-biphenyl)[2-(2'-amino-1,1'-biphenyl)] palladium (II) CAS:1310584-14-5	C₄₅H₅₇ClNPPd

Potassium Boc-protected secondary aminomethyltrifluoroborates: synthesis and Suzuki-Miyaura cross-coupling reactions.

Abstract

Related Compounds