Bioorganic & Medicinal Chemistry 2006-06-01

Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi.

Ana Cristina Lima Leite, Renata Souza de Lima, Diogo Rodrigo de M Moreira, Marcos Veríssimo de O Cardoso, Ana Carolina Gouveia de Brito, Luciene Maria Farias Dos Santos, Marcelo Zaldini Hernandes, Alice Costa Kiperstok, Ricardo Santana de Lima, Milena B P Soares

Index: Bioorg. Med. Chem. 14(11) , 3749-57, (2006)

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Abstract

A novel series of thiosemicarbazone and aminoacyl-thiazolidones derivatives were synthesized. Their structure suggests that these compounds could have anti-Trypanosoma cruzi activity. Biological evaluation indicates that some of these compounds are able to inhibit the growth of T. cruzi in concentrations non-cytotoxic to mammalian cells. Docking studies were carried out in order to investigate the binding pattern of these compounds for the T. cruzi cruzain (TCC) protein, and these showed a significant correlation with experimental data.