Tetrahedron Letters

Flavin-catalyzed aerobic oxidation of sulfides in aqueous media

Y Imada, T Kitagawa, HK Wang, N Komiya, T Naota

Index: Imada, Yasushi; Kitagawa, Takahiro; Wang, Han-Kun; Komiya, Naruyoshi; Naota, Takeshi Tetrahedron Letters, 2013 , vol. 54, # 7 p. 621 - 624

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Citation Number: 25

Abstract

An aerobic, organocatalytic, and aqueous method for the oxidation of sulfides is described. Synthetic flavin, 5-ethyl-3, 7, 8, 10-tetramethylisoalloxazinium perchlorate, acts as an efficient catalyst for the oxidation of sulfides in water under an oxygen atmosphere (1atm) with the assistance of ascorbic acid as a reductant. This is an inexpensive, convenient, and environmentally benign method for the selective oxidative transformation of sulfides into ...