A new route to cevimeline

C Pramanik, P Patil, S Kotharkar, NK Tripathy…

Index: Pramanik, Chinmoy; Patil, Pradip; Kotharkar, Sandeep; Tripathy, Narendra K.; Gurjar, Mukund K. Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3043 - 3045

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Abstract

Cevimeline hydrochloride (1, Fig. 1), chemically known as cis-2-methylspiro(1,3-oxathiolane- 5,3)quinuclidine, exists as a racemic mixture, an oral muscarinic agent that has been recently approved for the treatment of xerostomia in the setting of Sjogren's syndrome. 1 Sjogren's syndrome is a systemic chronic inflammatory disorder characterized by xerostomia, anhidrosis, and conjunctivitis sicca due to lymphocytic infiltration of exocrine organs, such as salivary, sweat, and ...