e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Tetrahedron letters

A novel and convenient method for trifluoromethylation of organic halides using CF 3 SiR'3/KF/Cu (I) system

H Urata, T Fuchikami

Index: Urata, Hisao; Fuchikami, Takamasa Tetrahedron Letters, 1991 , vol. 32, # 1 p. 91 - 94

Full Text: HTML

Citation Number: 211

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Fluoride ion induced cross-coupling reaction of organic halides with trifluoromethyltrialkylsilanes takes place in the presence of Cu(I) salts under mild reaction conditions to give the corresponding trifluoromethylated products in high yields. ... Kruse, A., Siegemund, G., Schumann, DCA, ...

4-Iodotoluene Structure

Trimethyl(pentafluoroethyl)silane Structure

Trimethyl(penta...

~%

1-Methyl-4-(pentafluoroethyl)benzene Structure

1-Methyl-4-(pen...

4-Iodoanisole Structure

Triethyl(trifluoromethyl)silane Structure

Triethyl(triflu...

~%

4-Trifluoromethylanisole Structure

4-Trifluorometh...

1-methoxy-4-(1,1,2,2,2-pentafluoroethyl)benzene Structure

1-methoxy-4-(1,...

4-Iodotoluene Structure

Triethyl(trifluoromethyl)silane Structure

Triethyl(triflu...

~%

2-Methylbenzotrifluoride Structure

2-Methylbenzotr...

1-Iodonaphthalene Structure

1-Iodonaphthalene

Trimethyl(pentafluoroethyl)silane Structure

Trimethyl(penta...

~%

1-(1,1,2,2,2-pentafluoroethyl)naphthalene Structure

1-(1,1,2,2,2-pe...

2-IODONAPHTHALENE Structure

2-IODONAPHTHALENE

Triethyl(trifluoromethyl)silane Structure

Triethyl(triflu...

~%

2-(trifluoromethyl)naphthalene Structure

2-(trifluoromet...

1-Iodo-4-nitrobenzene Structure

1-Iodo-4-nitrob...

Trimethyl(heptafluoropropyl)silane Structure

Trimethyl(hepta...

~%

1-nitro-4-(1,1,2,2,2-pentafluoroethyl)benzene Structure

1-nitro-4-(1,1,...

1-Iodo-4-nitrobenzene Structure

1-Iodo-4-nitrob...

Trimethyl(pentafluoroethyl)silane Structure

Trimethyl(penta...

~%

1-nitro-4-(1,1,2,2,2-pentafluoroethyl)benzene Structure

1-nitro-4-(1,1,...

1-Iodo-4-nitrobenzene Structure

1-Iodo-4-nitrob...

Triethyl(trifluoromethyl)silane Structure

Triethyl(triflu...

~0%

4-Nitrobenzotrifluoride Structure

4-Nitrobenzotri...

1-nitro-4-(1,1,2,2,2-pentafluoroethyl)benzene Structure

1-nitro-4-(1,1,...

3-Iodotoluene Structure

Triethyl(trifluoromethyl)silane Structure

Triethyl(triflu...

~%

1-Methyl-3-(trifluoromethyl)benzene Structure

1-Methyl-3-(tri...

Benzyl bromide Structure

Triethyl(trifluoromethyl)silane Structure

Triethyl(triflu...

~%

(2,2,2-Trifluoroethyl)benzene Structure

(2,2,2-Trifluor...

1-Iodo-4-nitrobenzene Structure

1-Iodo-4-nitrob...

Triethyl(trifluoromethyl)silane Structure

Triethyl(triflu...

~97%

4-Nitrobenzotrifluoride Structure

4-Nitrobenzotri...

1-nitro-4-(1,1,2,2,2-pentafluoroethyl)benzene Structure

1-nitro-4-(1,1,...

1-Chloro-4-iodobenzene Structure

1-Chloro-4-iodo...

Triethyl(trifluoromethyl)silane Structure

Triethyl(triflu...

~%

4-Chlorobenzotrifluoride Structure

4-Chlorobenzotr...